Researchers enable mRNA vaccines customization with novel processes

By Sakina Raj  | Date: 2022-06-09

Researchers enable mRNA vaccines customization with novel processes

Researchers at Nagoya University in Japan have designed a new chemically driven process that could potentially prove to be a crucial milestone in the development of customized mRNA vaccines catering to a broad range of diseases.

The potential breakthrough may allow manufacturers to affordably mass-produce mRNA vaccines.

As per credible sources, a group of researchers from Nagoya University - led by Professor Hiroshi Abe and accompanied by Associated Professor Naoko Abe of the Graduate School of Science - has created the first fully chemical synthesis technique for mRNA.

As a part of the study, the researchers synthesized some portion of the mRNA called the cap – a very crucial part as it promotes the translation of the strand into proteins and helps prevent any degradation and harm to the mRNA.

At present, synthetic mRNA is prepared using two biological methods that depend on enzymes to infuse the cap structure into the mRNA.

The researchers witnessed that their chemical-only technique was able to synthesize a range of chemically modified mRNA strands consisting of a cap structure, which is believed to help create customized vaccines against a spectrum of infectious diseases including cancers and viruses.

According to Professor Abe, introduction of such chemical modifications allow mRNA to become stable, which may ultimately help develop advanced and more effective mRNA vaccines with extended shelf-life.  

Abe further cited that it could also allow mRNA to be administered directly, eliminating the need for lipid nanoparticles – prominently used in administration of current vaccines.

Essentially, the researchers believe that the new development has the potential to introduce next generation of vaccines and hope that the capping method will play a crucial role in the development of RNA therapeutics.

Ideally, mRNA vaccines show cells how to make a protein that can boost immune response and strengthen the body’s natural defenses to fight any foreign virus.

Notably, the inability of the existing vaccines based on biological processes to derive the exact molecular makeup of mRNA restricts their use in the development of effective vaccines against constantly modifying variants. This is thus expected to necessitate more effective methods for synthesis.

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Sakina Raj

Sakina Raj

Armed with a degree in English Literature, Sakina chose to explore the world of content writing and pursue it as a career. Sakina has been playing with words for over five years now and currently pens down articles relating to diverse domains for BonafideNews and vari...

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